Directory
BOSCH PITA, Miguel
Ext. 5214
Department of Basic Areas
Neural Systems Plasticity Group (NeuroPlast)
BOSCH PITA, Miguel
CV
Teacher profile
Professor Col.laborador
Basic Areas, DEPARTMENT OF BASIC SCIENCIES. Universitat Internacional de Catalunya
Academic curriculum
- Neurociències Universitat de Barcelona
- Bioquímica Universitat de Barcelona
Research interests
Estic interessat en els mecanismes moleculars de l'aprenentatge i la memòria, i en el seu deteriorament en malalties neurodegeneratives i psiquiàtriques. La meva recerca pretén entendre com s'emmagatzema la informació al sistema nerviós, des de la sinapsi individual fins a la xarxa neuronal. Un aspecte clau de la meva recerca és l'ús de tecnologies avançades basades en la llum, com ara la microscòpia multifotònica, l'optogenètica i la fotofarmacologia. Desenvolupo nous mètodes i aplicacions d'aquestes tecnologies per visualitzar i manipular, en temps real, els esdeveniments de plasticitat neuronal a múltiples nivells: circuits (per exemple, ones cerebrals), neurones, i sinapsis individuals (per exemple, potenciació i depressió a llarg termini). A més aplico aquests mètodes per desenvolupar fototeràpies basades en fotofarmacologia per a malalties com els trastorns de l'espectre autista i l'epilèpsia.
Professional experience
- Current positions: Assistant Professor (UIC-Barcelona, since September 2020); Group Leader of the Synaptic Plasticity Laboratory (since January 2021) Associate researcher (INc-UAB, since January 2022).
- Associate researcher, laboratory of M.V. Sánchez-Vives, Systems Neuroscience, Biomedical “Agustí Pi i Sunyer” Research Institute (IDIBAPS), Barcelona, Spain (May 2018-January 2021).
- MSCA researcher, Pau Gorostiza laboratory, Nanoprobes and Nanoswitches Lab, Institute of Bioengineering of Catalonia (IBEC), Barcelona, Spain (March 2015-April 2018).
- Research Scientist, Mark F. Bear Laboratory, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (May 2012-September 2014).
- Visiting research scientist, Yasunori Hayashi laboratory, Brain Science Institute (BSI), RIKEN, Wako, Japan (short stays: September-December 2010 and January-April 2012).
- FRAXA Postdoctoral Fellowship, Mark F. Bear Lab, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (August 2009-April 2012).
- “Beatriu de Pinós” Postdoctoral Fellowship, Yasunori Hayashi laboratory, RIKEN-MIT Neuroscience Research Center, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (from 2005-July 2009).
- Postdoctoral Associate, Tetsuo Yamamori laboratory, Division of Brain Biology, National. Institute of Basic Biology (NIBB), Okazaki, Japan (May-November 2005).
- Doctor. in Neuroscience. Department of Cell Biology and Pathological Anatomy, Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain (August 2000-April 19, 2005). Supervisors: Jordi Alberch and Josep M. Canals. Thesis title: Cell therapy in Huntington's disease models.
- Predoctoral internship, laboratory of Ernest Arenas, Biochemistry and Medical Biophysics Department, Karolinska Institute (KI), Stockholm, Sweden (August-November 2002).
- BS in Biochemistry. Faculty of Biology, Faculty of Chemistry, University of Barcelona (UB), Barcelona, Spain (February 2000).
- Degree Practices:
1) Antonio Zorzano Laboratory, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain (April-June 2000);
2) Jordi Bernués Laboratory, Department of Cellular and Molecular Biology, Institute of Molecular Biology of Barcelona (IBMB), CSIC, Spain (October 1999 – February 2000);
3) Marta Cascante Laboratory, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain (July-August 1997; July-August 1998).
- Associate researcher, laboratory of M.V. Sánchez-Vives, Systems Neuroscience, Biomedical “Agustí Pi i Sunyer” Research Institute (IDIBAPS), Barcelona, Spain (May 2018-January 2021).
- MSCA researcher, Pau Gorostiza laboratory, Nanoprobes and Nanoswitches Lab, Institute of Bioengineering of Catalonia (IBEC), Barcelona, Spain (March 2015-April 2018).
- Research Scientist, Mark F. Bear Laboratory, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (May 2012-September 2014).
- Visiting research scientist, Yasunori Hayashi laboratory, Brain Science Institute (BSI), RIKEN, Wako, Japan (short stays: September-December 2010 and January-April 2012).
- FRAXA Postdoctoral Fellowship, Mark F. Bear Lab, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (August 2009-April 2012).
- “Beatriu de Pinós” Postdoctoral Fellowship, Yasunori Hayashi laboratory, RIKEN-MIT Neuroscience Research Center, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (from 2005-July 2009).
- Postdoctoral Associate, Tetsuo Yamamori laboratory, Division of Brain Biology, National. Institute of Basic Biology (NIBB), Okazaki, Japan (May-November 2005).
- Doctor. in Neuroscience. Department of Cell Biology and Pathological Anatomy, Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain (August 2000-April 19, 2005). Supervisors: Jordi Alberch and Josep M. Canals. Thesis title: Cell therapy in Huntington's disease models.
- Predoctoral internship, laboratory of Ernest Arenas, Biochemistry and Medical Biophysics Department, Karolinska Institute (KI), Stockholm, Sweden (August-November 2002).
- BS in Biochemistry. Faculty of Biology, Faculty of Chemistry, University of Barcelona (UB), Barcelona, Spain (February 2000).
- Degree Practices:
1) Antonio Zorzano Laboratory, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain (April-June 2000);
2) Jordi Bernués Laboratory, Department of Cellular and Molecular Biology, Institute of Molecular Biology of Barcelona (IBMB), CSIC, Spain (October 1999 – February 2000);
3) Marta Cascante Laboratory, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain (July-August 1997; July-August 1998).
Publications
Articles
- Camassa, A.; Barbero-Castillo, A.; Bosch, M.; DaSilva, M.; Masvidal, E.; Villa, R.; Guimera-Brunet, A.; Sanchez-Vives, M., (2024), "Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states", Nanoscale Horizons, ISSN: 2055-6756.
- Ortega-Gascó, A.; Parcerisas, A.; Hino, K.; Herranz, V.; Ulloa, F.; Elias, A.; Bosch, M.; García, J.; Simó, S.; Pujadas, L.; Soriano, E., (2022), "Regulation of adult neurogenesis and neuronal differentiation by Neural Cell Adhesion Molecule 2 (NCAM2)", bioRxiv.
- Mendoza, M.B.; Gutiérrez, S.; Ortiz, R.; Moreno, D.; Dermit, M.; Dodel, M.; Rebollo, E.; Bosch, M.; Mardakheh, F.K.; Gallego, C., (2021), "The elongation factor eEF1A2 controls translation and actin dynamics in dendritic spines", Science Signaling, vol. 14, No. 691, ISSN: 1945-0877.
- Parcerisas, A.; Ortega-Gascó, A.; Hernaiz, M.; Odena, M.; Ulloa, F.; De Oliveira, E.; Bosch, M.; Pujadas, L.; Soriano, E., (2021), "New partners identified by mass spectrometry assay reveal functions of NCAM2 in neuronal cytoskeleton organization", International Journal of Molecular Sciences, vol. 22, No. 14, ISSN: 1422-0067.
- Gomila , A.; Rustler, K.; Maleeva, G.; Nin-Hill, A.; Wutz, D.; Bautista, A.; Rovira, X.; Bosch, M.; Mukhametova, E.; Petukhova, E.; Ponomareva, D.; Mukhamedyarov, M.; Peiretti, F.; Alfonso, M.; Rovira, C.; König, B.; Bregestovski, P.; Gorostiza, P., (2020), "Photocontrol of endogenous glycine receptors in vivo", Cell Chemical Biology, vol. 27, No. 11, pp. 1425-1433, ISSN: 2451-9448.
- Thomazeau, A.; Bosch, M.; Essayan-Perez, S.; Barnes, S.; de Jesús-Cort́es, H.; Bear, M.F., (2020), "Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice", Molecular psychiatry, ISSN: 1359-4184.
- Cabré, G.; Garrido-Charles, A.; Moreno, M.; Bosch, M.; Porta, M.; Krieg, M.; Gascón, M.; Camarero, N.; Gelabert, R.; Lluch, J. M.; Busqué, F.; Hernando, J.; Gorostiza, P.; Alibés, R., (2019), "Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation", Nature communications, vol. 10, No. 1, ISSN: 2041-1723.
- Pittolo, S.; Lee, H.; Lladó, A.; Tosi, S.; Bosch, M.; Bardia, L.; Gómez, X.; Llebaria, A.; Soriano, E.; Colombelli, J.; Poskanzer, K.; Perea, G.; Gorostiza, P., (2019), "Reversible silencing of endogenous receptors in intact brain tissue using two-photon pharmacology", PNAS - National Academy of Sciences. Proceedings (Online), vol. 116, No. 27, pp. 13680-13689, ISSN: 1091-6490.
- Borovac, J.; Bosch, M.; Okamoto, K., (2018), "Regulation of actin dynamics during structural plasticity of dendritic spines: signalling messengers and actin-binding proteins", Molecular and cellular neuroscience, vol. 91, pp. 122-130, ISSN: 1044-7431.
- Bosch, M.; Castro, J.; Saneyoshi, T.; Matsuno, H.; Sur, M.; Hayashi, Y., (2014), "Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-term Potentiation", NEURON, vol. 82, No. 2, pp. 444-459, ISSN: 1097-4199.
- Huang, Z.; Zhang, X.; Bosch, M.; Smith, S.; Lippard, S., (2013), "Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc", Metallomics, vol. 5, No. 6, pp. 648-655, ISSN: 1756-591X.
- Bosch, M.; Hayashi, Y., (2012), "Structural Plasticity of Dendritic Spines", CURRENT OPINION IN NEUROBIOLOGY, vol. 22, No. 3, pp. 383-388, ISSN: 1873-6882.
Book chapters
- Hayashi, Y.; Bosch, M.; Hosokawa, T.; Liu, P.; Saneyoshi, T., (2024), "Molecular mechanisms underlying synaptic tagging and consolidation", Synaptic tagging and capture.
- Bosch, M., (11/12/2016), "Photomarking Relocalization Technique for Correlated Two-Photon and Electron Microcopy Imaging of Single Stimulated Synapses", Synapse Development: Methods in Molecular Biology., pp. 185-214. ISBN: 978-1-4939-6688-2.
- Bosch, M., (27/01/2012), "Roles of neuronal activity-induced gene products in Hebbian and homeostatic synaptic plasticity, tagging and capture", Synaptic plasticity. Dynamics, development and disease, pp. 335-354, Springer, Vienna. ISBN: 978-3-7091-0932-8.
Projects and research
-
Validation of transcriptional biomarkers for therapeutic improvement in intellectual disability using extracellular vesicles01/01/2023 - 31/08/2025IP: Bosch, M.
Fundació la Marató de TV3
-
Proyecto estatal de I+D Generación de Conocimiento: "Photopharmacological interrogation of the interplay between synaptic plasticity and brain waves in models of autism"01/09/2021 - 01/09/2024IP: Bosch, M.
MINISTERIO DE CIENCIA E INNOVACION
-
Proyecto Retos I+D+i para jóvenes investigadores sin vinculación o con vinculación temporal01/05/2015 - 30/04/2017IP: Bosch, M.
Agencia EStatal de Investigación
Activities
- FENS FORUM OF NEUROSCIENCE Presentació de poster "Photoactivation of individual synapses in vivo with covalent photoswitches targeting endogenous glutamate receptors", 2022.
- Congreso de la Sociedad Española de Neurociencia Ponència "Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wildtype and fragile X model mice", 2021.