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Our teaching and research team
ZAGMUTT CAROCA, Sebastián Ignacio

ZAGMUTT CAROCA, Sebastián Ignacio

Professor Lector
DEPARTMENT OF BASIC SCIENCIES
Department of Basic Areas
From cell metabolism to metabolic diseases (METADIS)

Contact

szagmutt@uic.es
ORCID
  • Academic training
  • Publications
    • Articles
  • Subjects taught
Doctor in Biotechnology, UNIVERSITAT DE BARCELONA
Master in Biomedical Sciences: Clinical Biochemistry and Immunohematology, UNIVERSIDAD DE CHILE
Graduated Medical Technologist, UNIVERSIDAD DE CHILE
Graduate in Medical Technology, UNIVERSIDAD DE CHILE
Diploma in Competency-Based Higher Education, UNIVERSIDAD DE CHILE
  • Aging Cell, Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice
    Name: Ibeas, K.; Griñán-Ferré, C.; del Mar Romero, M.; Sebastián , D.; Bastías-Pérez, M.; Gomez, R.; Soler-Vázquez, M.; Zagmutt, S.; Pallás, M.; Castell, M.; Belsham, D.; Mera, P.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2024
    Vol.: 23 No.: 2
    DOI: https://dx.doi.org/10.1111/acel.14047 ISSN or title: 14749718
  • Biology of Sex Differences, CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
    Name: Zagmutt, S.; Mera, P.; González, I.; Ibeas, K.; Romero, M.; Obri, A.; Martin, B.; Esteve, A.; Soler-Vázquez, M.C.; Bastias, M.; Cañes, L.; Augé, E.; Pelegri, C.; Vilaplana, J.; Ariza, X.; García, J.; Martinez, J.; Casals, N; López, M.; Palmiter, R.; Sanz, E.; Quintana, A.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2023
    Vol.: 14 No.: 1
    DOI: https://dx.doi.org/10.1186/s13293-023-00498-8 ISSN or title: 2042-6410
  • Metabolic engineering, Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice
    Name: Soler-Vázquez, M.C.; Romero, M.; Todorcevic, M.; Delgado, K.; Calatayud, C.; Benitez, A.; La Chica, M.; Mera, P.; Zagmutt, S.; Bastías, M.; Ibeas, K.; Casals, N; Escolà, J.; Llorente-Cortés, V.; Consiglio, A.; Serra, D.; Herrero, L. Role: Autor Publishing date: 2023
    Start page: 256 End page: 272 Vol.: 77
    DOI: https://dx.doi.org/10.1016/j.ymben.2023.04.010 ISSN or title: 1096-7176
  • Nature Metabolism, Angiocrine polyamine production regulates adiposity
    Name: Monelli, E.; Villacampa, P.; Zabala-Letona; Martinez-Romero, A.; Llena, J.; Beiroa, D.; Gouveia, L.; Chivite, I.; Zagmutt, S.; Gama-Perez, P.; Osorio-Conles, O.; Muixi, L.; Martinez-Gonzalez, A.; Castillo, S.; Martín-Martín, N.; Castel, P.; Valcarcel-Jimenez, L.; Garcia-Gonzalez, I.; Villena, J.; Fernandez-Ruiz, S.; Serra, D.; Herrero, L.; Benedito, R.; Garcia-Roves, P.; Vidal, J.; Cohen, P.; Nogueiras, R.; Claret , M.; Carracedo, A.; Graupera, M. Role: Autor Publishing date: 2023
    Start page: 327 End page: 343 Vol.: 4 No.: 3
    DOI: https://dx.doi.org/10.1038/s42255-022-00544-6 ISSN or title: 25225812
  • Biomaterials science, Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
    Name: Garcia, J.; Paraiso, W.; Zagmutt, S.; Fosch, A.; Reguera, AC.; Alzina, S.; Sánchez, L.; Fukushima, S.; Toh, K.; Casals, N; Serra, D.; Herrero, L.; Garcia, J.; Kataoka, K.; Ariza, X.; Quader, S.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2023
    Start page: 2336 End page: 2347 Vol.: 11
    DOI: https://dx.doi.org/10.1039/d2bm01751b ISSN or title: 2047-4830
  • JOURNAL OF NEUROENDOCRINOLOGY, Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: A promising strategy to regulate energy balance
    Name: Rodriguez-Rodriguez, R.; Fosch, A.; Garcia, J.; Zagmutt, S.; Casals, N Role: Autor Publishing date: 2023
    Vol.: 35 No.: 9
    DOI: https://dx.doi.org/10.1111/jne.13234 ISSN or title: 1365-2826
  • Cell death and disease, To be or not to be a fat burner, that is the question for cpt1c in cancer cells
    Name: Fadó, R.; Zagmutt, S.; Herrero, L.; Muley, H.; Rodriguez-Rodriguez, R.; Bi, H.; Serra, D.; Casals, N Role: Autor Publishing date: 2023
    Vol.: 14 No.: 1
    DOI: https://dx.doi.org/10.1038/s41419-023-05599-1 ISSN or title: 2041-4889
  • International Journal of Molecular Sciences, Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids
    Name: Fosch, A.; Rodriguez, M.; Miralpeix, C.; Zagmutt, S.; Larrañaga, M.; Reguera, AC.; Garcia, J.; Herrero, L.; Serra, D.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2023
    Vol.: 24 No.: 2
    DOI: https://dx.doi.org/10.3390/ijms24021697 ISSN or title: 1422-0067
  • Antioxidants, Integrated Metabolomics, Lipidomics, and Genomics Reveal the Presence of a New Biomarker, Butanediol Glucuronide, Associated with the Activation of Liver Ketogenesis and Lipid Oxidation by Tomato-Based Sofrito in Obese Rats
    Name: Rinaldi de Alvarenga, J.; Garcia, M.; Ulaszewska, M.; Zagmutt, S.; Perez-Montero, M.; Vrhovsek, U.; Lamuela Raventos, R.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2022
    Vol.: 11 No.: 11
    DOI: https://dx.doi.org/10.3390/antiox11112165 ISSN or title: 2076-3921
  • Nutrients, Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic Acids in Obesity and Related Diseases
    Name: Claro-Cala, C.; Jiménez-Altayó, F.; Zagmutt, S.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2022
    Vol.: 14 No.: 8
    DOI: https://dx.doi.org/10.3390/nu14081606 ISSN or title: 2072-6643
  • Cellular and molecular life sciences, Hypothalamic endocannabinoids in obesity: an old story with new challenges
    Name: Miralpeix, C.; Reguera, AC.; Fosch, A.; Zagmutt, S.; Casals, N; Cota, D.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2021
    Start page: 7469 End page: 7490 Vol.: 78 No.: 23
    DOI: https://dx.doi.org/10.1007/s00018-021-04002-6 ISSN or title: 1420-682X
  • Biomaterials science, Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells
    Name: Paraiso, W.; Garcia, J.; Ariza, J.; Zagmutt, S.; Fukushima, S.; Garcia, J.; Mochida, Y.; Serra, D.; Herrero, L.; Kinoh, H.; Casals, N; Kataoka, K.; Rodriguez-Rodriguez, R.; Quader, S. Role: Autor Publishing date: 2021
    Start page: 7076 End page: 7091 Vol.: 9 No.: 21
    DOI: https://dx.doi.org/10.1039/d1bm00689d ISSN or title: 2047-4830
  • International Journal of Molecular Sciences, New insights of sf1 neurons in hypothalamic regulation of obesity and diabetes
    Name: Fosch, A.; Zagmutt, S.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2021
    Vol.: 22 No.: 12
    DOI: https://dx.doi.org/10.3390/ijms22126186 ISSN or title: 1422-0067
  • Molecular neurobiology, Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex
    Name: Mir, J.; Zagmutt, S.; Lichtenstein, M.; Casals, N; Herrero, L.; Serra, D. Role: Autor Publishing date: 2018
    Start page: 7216 End page: 7228 Vol.: 55
    DOI: https://dx.doi.org/10.1007/s12035-018-0921-3 ISSN or title: 0893-7648
Course 2024-2025 - Period: 01/09/2024 - 31/08/2025
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Work Placement
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Final Master's Degree Project
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum I
    • - Practicum II
Course 2023-2024 - Period: 01/09/2023 - 31/08/2024
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Techniques for Biomedical Analysis I
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum II
    • - Final Master's Degree Project
    • - Practicum I
Course 2022-2023 - Period: 01/09/2022 - 31/08/2023
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Work Placement
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Techniques for Biomedical Analysis I
Course 2021-2022 - Period: 01/09/2021 - 31/08/2022
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis II
    • - Introduction to Biomedicine
    • - Techniques for Biomedical Analysis I
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Work Placement
Course 2020-2021 - Period: 01/09/2020 - 31/08/2021
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Introduction to Biomedicine
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II

Academic training

Doctor in Biotechnology, UNIVERSITAT DE BARCELONA
Master in Biomedical Sciences: Clinical Biochemistry and Immunohematology, UNIVERSIDAD DE CHILE
Graduated Medical Technologist, UNIVERSIDAD DE CHILE
Graduate in Medical Technology, UNIVERSIDAD DE CHILE
Diploma in Competency-Based Higher Education, UNIVERSIDAD DE CHILE

Publications

Articles

  • Aging Cell, Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice
    Name: Ibeas, K.; Griñán-Ferré, C.; del Mar Romero, M.; Sebastián , D.; Bastías-Pérez, M.; Gomez, R.; Soler-Vázquez, M.; Zagmutt, S.; Pallás, M.; Castell, M.; Belsham, D.; Mera, P.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2024
    Vol.: 23 No.: 2
    DOI: https://dx.doi.org/10.1111/acel.14047 ISSN or title: 14749718
  • Biology of Sex Differences, CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
    Name: Zagmutt, S.; Mera, P.; González, I.; Ibeas, K.; Romero, M.; Obri, A.; Martin, B.; Esteve, A.; Soler-Vázquez, M.C.; Bastias, M.; Cañes, L.; Augé, E.; Pelegri, C.; Vilaplana, J.; Ariza, X.; García, J.; Martinez, J.; Casals, N; López, M.; Palmiter, R.; Sanz, E.; Quintana, A.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2023
    Vol.: 14 No.: 1
    DOI: https://dx.doi.org/10.1186/s13293-023-00498-8 ISSN or title: 2042-6410
  • Metabolic engineering, Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice
    Name: Soler-Vázquez, M.C.; Romero, M.; Todorcevic, M.; Delgado, K.; Calatayud, C.; Benitez, A.; La Chica, M.; Mera, P.; Zagmutt, S.; Bastías, M.; Ibeas, K.; Casals, N; Escolà, J.; Llorente-Cortés, V.; Consiglio, A.; Serra, D.; Herrero, L. Role: Autor Publishing date: 2023
    Start page: 256 End page: 272 Vol.: 77
    DOI: https://dx.doi.org/10.1016/j.ymben.2023.04.010 ISSN or title: 1096-7176
  • Nature Metabolism, Angiocrine polyamine production regulates adiposity
    Name: Monelli, E.; Villacampa, P.; Zabala-Letona; Martinez-Romero, A.; Llena, J.; Beiroa, D.; Gouveia, L.; Chivite, I.; Zagmutt, S.; Gama-Perez, P.; Osorio-Conles, O.; Muixi, L.; Martinez-Gonzalez, A.; Castillo, S.; Martín-Martín, N.; Castel, P.; Valcarcel-Jimenez, L.; Garcia-Gonzalez, I.; Villena, J.; Fernandez-Ruiz, S.; Serra, D.; Herrero, L.; Benedito, R.; Garcia-Roves, P.; Vidal, J.; Cohen, P.; Nogueiras, R.; Claret , M.; Carracedo, A.; Graupera, M. Role: Autor Publishing date: 2023
    Start page: 327 End page: 343 Vol.: 4 No.: 3
    DOI: https://dx.doi.org/10.1038/s42255-022-00544-6 ISSN or title: 25225812
  • Biomaterials science, Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
    Name: Garcia, J.; Paraiso, W.; Zagmutt, S.; Fosch, A.; Reguera, AC.; Alzina, S.; Sánchez, L.; Fukushima, S.; Toh, K.; Casals, N; Serra, D.; Herrero, L.; Garcia, J.; Kataoka, K.; Ariza, X.; Quader, S.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2023
    Start page: 2336 End page: 2347 Vol.: 11
    DOI: https://dx.doi.org/10.1039/d2bm01751b ISSN or title: 2047-4830
  • JOURNAL OF NEUROENDOCRINOLOGY, Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: A promising strategy to regulate energy balance
    Name: Rodriguez-Rodriguez, R.; Fosch, A.; Garcia, J.; Zagmutt, S.; Casals, N Role: Autor Publishing date: 2023
    Vol.: 35 No.: 9
    DOI: https://dx.doi.org/10.1111/jne.13234 ISSN or title: 1365-2826
  • Cell death and disease, To be or not to be a fat burner, that is the question for cpt1c in cancer cells
    Name: Fadó, R.; Zagmutt, S.; Herrero, L.; Muley, H.; Rodriguez-Rodriguez, R.; Bi, H.; Serra, D.; Casals, N Role: Autor Publishing date: 2023
    Vol.: 14 No.: 1
    DOI: https://dx.doi.org/10.1038/s41419-023-05599-1 ISSN or title: 2041-4889
  • International Journal of Molecular Sciences, Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids
    Name: Fosch, A.; Rodriguez, M.; Miralpeix, C.; Zagmutt, S.; Larrañaga, M.; Reguera, AC.; Garcia, J.; Herrero, L.; Serra, D.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2023
    Vol.: 24 No.: 2
    DOI: https://dx.doi.org/10.3390/ijms24021697 ISSN or title: 1422-0067
  • Antioxidants, Integrated Metabolomics, Lipidomics, and Genomics Reveal the Presence of a New Biomarker, Butanediol Glucuronide, Associated with the Activation of Liver Ketogenesis and Lipid Oxidation by Tomato-Based Sofrito in Obese Rats
    Name: Rinaldi de Alvarenga, J.; Garcia, M.; Ulaszewska, M.; Zagmutt, S.; Perez-Montero, M.; Vrhovsek, U.; Lamuela Raventos, R.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2022
    Vol.: 11 No.: 11
    DOI: https://dx.doi.org/10.3390/antiox11112165 ISSN or title: 2076-3921
  • Nutrients, Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic Acids in Obesity and Related Diseases
    Name: Claro-Cala, C.; Jiménez-Altayó, F.; Zagmutt, S.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2022
    Vol.: 14 No.: 8
    DOI: https://dx.doi.org/10.3390/nu14081606 ISSN or title: 2072-6643
  • Cellular and molecular life sciences, Hypothalamic endocannabinoids in obesity: an old story with new challenges
    Name: Miralpeix, C.; Reguera, AC.; Fosch, A.; Zagmutt, S.; Casals, N; Cota, D.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2021
    Start page: 7469 End page: 7490 Vol.: 78 No.: 23
    DOI: https://dx.doi.org/10.1007/s00018-021-04002-6 ISSN or title: 1420-682X
  • Biomaterials science, Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells
    Name: Paraiso, W.; Garcia, J.; Ariza, J.; Zagmutt, S.; Fukushima, S.; Garcia, J.; Mochida, Y.; Serra, D.; Herrero, L.; Kinoh, H.; Casals, N; Kataoka, K.; Rodriguez-Rodriguez, R.; Quader, S. Role: Autor Publishing date: 2021
    Start page: 7076 End page: 7091 Vol.: 9 No.: 21
    DOI: https://dx.doi.org/10.1039/d1bm00689d ISSN or title: 2047-4830
  • International Journal of Molecular Sciences, New insights of sf1 neurons in hypothalamic regulation of obesity and diabetes
    Name: Fosch, A.; Zagmutt, S.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2021
    Vol.: 22 No.: 12
    DOI: https://dx.doi.org/10.3390/ijms22126186 ISSN or title: 1422-0067
  • Molecular neurobiology, Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex
    Name: Mir, J.; Zagmutt, S.; Lichtenstein, M.; Casals, N; Herrero, L.; Serra, D. Role: Autor Publishing date: 2018
    Start page: 7216 End page: 7228 Vol.: 55
    DOI: https://dx.doi.org/10.1007/s12035-018-0921-3 ISSN or title: 0893-7648
Course 2024-2025 - Period: 01/09/2024 - 31/08/2025
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Work Placement
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Final Master's Degree Project
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum I
    • - Practicum II
Course 2023-2024 - Period: 01/09/2023 - 31/08/2024
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Techniques for Biomedical Analysis I
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum II
    • - Final Master's Degree Project
    • - Practicum I
Course 2022-2023 - Period: 01/09/2022 - 31/08/2023
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Work Placement
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Techniques for Biomedical Analysis I
Course 2021-2022 - Period: 01/09/2021 - 31/08/2022
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis II
    • - Introduction to Biomedicine
    • - Techniques for Biomedical Analysis I
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Work Placement
Course 2020-2021 - Period: 01/09/2020 - 31/08/2021
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Introduction to Biomedicine
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II